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Tapentadol is a centrally acting analgesic that is used for the treatment of moderate to severe acute and chronic pain. It is a synthetic opioid that functions as both a μ-opioid receptor agonist and a norepinephrine reuptake inhibitor (NRI), and gives it a dual mechanism of action within 20 to 30 minutes. Tapentadol is considered to have a lower incidence of gastrointestinal side effects compared to some traditional opioids, while still providing strong analgesic effects.

Tapentadol is available in immediate-release and extended-release formulations. The immediate-release form is typically prescribed for acute pain, and Its extended-release form is used for chronic pain conditions such as neuropathic pain associated with diabetic peripheral neuropathy or pain from musculoskeletal disorders.

There are certain common side effects wchich includes nausea, dizziness, drowsiness, constipation, and headache. Serious adverse effects may include respiratory depression, seizures, and risk of misuse, dependence, or addiction, as with other opioid medications. Tapentadol is classified as a controlled substance in many countries due to its potential for abuse.

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